Ginkgo Biloba Research Today is a free monthly online journal that collates and summarizes the latest research about Ginkgo Biloba, including details on ginkgo biloba, herbal remedies, side effects, benefits.

Effects of Ginkgolide on the development of NOS and AChE positive neurons in the embryonic basal forebrain.

Jin GH, Huang Z, Tan XF, Tian ML, Zhang XH, Qin JB, Xu HJ, Yew DT, Mak YT

Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Nantong University, Nantong 226001, China. jguohua@ntu.edu.cn

Extract of Ginkgo biloba (EGb) has been therapeutically used for several decades to increase peripheral and cerebral blood flow so as to prevent cardiovascular and neurovascular diseases. However, the role of EGb in neuroprotective effects has received much attention recently. In this study, we investigated the effect of EGb on the development of NOS and AChE positive neurons in the rat embryonic basal forebrain. The results showed that treated with EGb, the OD of MTT staining analysis, and the numbers, the cell sizes and circumferences of NOS and AChE positive neurons were greatly promoted. These data suggest that EGb had similar effects of the neurotrophins such as NGF and BDNF in promoting the development of NOS and AChE positive neurons in the rat embryonic basal forebrain.

Published 12 June 2006 in Cell Biol Int, 30(6): 500-4.
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