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Biotransformation of alpha-santonin by cell suspension cultures of five plants.

Yang L, Dai J, Sakai J, Ando M

College of Life and Environmental Sciences, The Central University for Nationalities, 100081, Beijing, P.R. China.

Cell suspension cultures of five plants (Catharanthus roseus, Ginkgo biloba, Platycodon grandiflorum, Taxus cuspidata, Phytolacca asinosa) were employed to bioconvert the eudesmanolide compound, alpha-santonin. Reactions occurring were hydroxylation (C-1, C-11 and C-15), reduction of the double bond [1(2) or 3(4)], rearrangment of the eudesmanolide skeleton to a guaianolide skeleton and lactone-ring hydrolysis. Four new compounds were identified.

Published 8 August 2005 in Biotechnol Lett, 27(11): 793-7.
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