Ginkgo Biloba Research Today is a free monthly online journal that collates and summarizes the latest research about Ginkgo Biloba, including details on ginkgo biloba, herbal remedies, side effects, benefits.

Biphasic effect of EGb761 on simulated ischemia-induced rat BMSC survival in vitro and in vivo.

Li S, Tang D, Xue Z, Zhang Z, Sun X, Liu Y, Dong H, Yin X, Zhang Z

Center of Biological Research, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China.

Published 2 May 2011 in Life Sci, 88(19): 853-63.
Full-text of this article is available online (may require subscription).

Articles on Ginkgo Biloba published 29 April 2011:

Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.   J Ethnopharmacol.

ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgo biloba leaves are traditionally used in China for its health-promoting properties. There is substantial experimental evidence to support the view that Ginkgo biloba extracts have neuroprotective properties under conditions such as hypoxia/ischemia. AIM OF STUDY: Although a number of studies have investigated that ginkgolide B, a purified terpene lactone component extracted from Ginkgo biloba leaves, is available "platelet activating factor (PAF) ... [Abstract] [Full-text]

Articles on Ginkgo Biloba published 28 April 2011:

Identification of novel pregnane X receptor activators from traditional Chinese medicines.   J Ethnopharmacol.

AIM OF THE STUDY: To investigate the ability of traditional Chinese medicines (TCMs) and their bioactive compounds to activate pregnane X receptor (PXR) signalling pathway. MATERIALS AND METHODS: We screened ethanol extracts of 28 commonly used TCMs for their capability to induce cytochrome P450 3A4 (CYP3A4) via PXR signalling pathway using a cell-based reporter gene assay combined with RT-PCR analysis. In addition, 34 bioactive components from these TCMs were examined for their potential to ... [Abstract] [Full-text]

Articles on Ginkgo Biloba published 26 April 2011:

Photoprotective Effects of Topical Formulations Containing a Combination of Ginkgo biloba and Green Tea Extracts.   Phytother Res.

The beneficial photoprotective effects of topical formulations containing combined extracts of Ginkgo biloba (GB) and green tea (GT) have not been investigated. The present study aims to assess the photoprotective effects of topical formulations containing GB and GT combined or not by applications on the dorsal skin of hairless mice prior to UVA/B irradiation. After 20 h, skin barrier damage (TEWL), erythema, histological alterations and sunburn cell formation were evaluated. The results ... [Abstract] [Full-text]

Articles on Ginkgo Biloba published 25 April 2011:

An efficient molecular docking method for adsorbent screening.   J Chromatogr B Analyt Technol Biomed Life Sci.

In this study, with flavonol glycosides (FG) and terpene lactones (TL) in ginkgo biloba extract (GBE) as the targets for separation, we investigated the effectiveness of molecular docking in adsorbent screening. Several polyamine-modified methyl acylate-co-divinylbenzene (MA-co-DVB) adsorbent models were built, and their affinity to rutin, quercetin and ginkgolide B (GB) was evaluated via molecular docking. The model of ethylenediamine-modified adsorbent showed the largest difference in ... [Abstract] [Full-text]

Central and Local Administration of Gingko Biloba Extract EGb 761(R) Inhibits Thermal Hyperalgesia and Inflammation in the Rat Carrageenan Model.   Anesth Analg, 112(5): 1226-31.

[Abstract] [Full-text]

Articles on Ginkgo Biloba published 19 April 2011:

Proanthocyanidins from Ginkgo biloba leaf extract and their radical scavenging activity.   Pharm Biol, 49(5): 471-6.

Context: Ginkgo biloba L (Ginkgoaceae) is a traditional herbal medicinal plant for the treatment of mild to moderate cognitive disorders, tinnitus, and dementia. These uses may be correlated with the presence of radical scavenging compounds. Objective: The chemical composition and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the flavan-3-ols and proanthocyanidins from G. biloba were studied. Material and methods: The compounds have been isolated using column ... [Abstract] [Full-text]

Articles on Ginkgo Biloba published 18 April 2011:

Protective effects of Ginkgo biloba extract in rats with hypoxia/reoxygenation-induced intestinal injury.   J Pediatr Surg, 46(4): 685-90.

[Abstract] [Full-text]

Biphasic effect of EGb761 on simulated ischemia-induced rat BMSC survival in vitro and in vivo.   Life Sci.

AIMS: The standardized extract from the leaves of Ginkgo biloba (EGb761) is applied as a phyto-pharmacon in therapy of diverse cardiovascular disorders. However, the effects of EGb761 on bone-marrow mesenchymal stem cells (BMSCs) transplanted into the ischemic myocardium currently remain uncertain. In this study, the dosage-effects of EGb761 on BMSC survival in vitro and in vivo were investigated. MAIN METHODS: The ischemic microenvironment of rat BMSCs was simulated by hypoxia/serum ... [Abstract] [Full-text]

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